The previous episode of "Grey's Anatomy" season 12 saw an awkward dinner party turn into a complete disaster when Meredith (Ellen Pompeo) revealed that Callie's (Sara Ramirez) new date, Penny (Samantha Sloyan), is one of the surgeons responsible for Derek's (Patrick Dempsey) death.

Episode 6, officially titled "The Me Nobody Knows," will see that mess spread out as Bailey (Chandra Wilson) forces Meredith to work together with the newly arrived resident who turns out to be Penny. The promotional trailer also showcases that right from the beginning, things will turn for the worst as Meredith criticizes everything Penny does.

"Is there any part of this job that you can handle?" Meredith is shown asking Penny after what appears to be a mishandled emergency with a patient. Penny does appear to try and make things work out by requesting things to not be awkward but Meredith simply tells her "then don't make it awkward."

The trailer ends on a low note as well, hinting that their problems won't be resolved in just one episode. There is a scene in the trailer where Meredith simply yells at Penny, demanding that the latter get off the patient's case. It isn't revealed if this is simply due to Meredith blaming Penny for Derek's death or because of Penny's mistakes while handling their patient.

When Penny is asked if she has a problem she immediately replies that Meredith is the cause.

However, Penny will have to worry about more than her working relationship with Meredith. A quick scene in the trailer also showcases Amelia (Caterina Scorsone) meeting Penny in the hospital, most likely shocked to learn that the latter now works there, and it is likely that the two will have a heated confrontation at some point in the episode.

"Grey's Anatomy" season 12 episode 6, "The Me Nobody Knows," airs this Nov. 5.