Come "Grey's Anatomy" season 13, things will be a lot different in Grey Sloan Memorial Hospital, especially for Amelia (Caterina Scorsone) and Owen (Kevin McKidd), who exchanged their vows in the season 12 finale.

Marriages aren't perfect and that holds true for Amelia and Owen. There's bound to be disaster that will put their relationship to the test in "Grey's Anatomy" season 13, although Scorsone hopes Amelia and Owen first get to savor the fact that they just got hitched.

"We really haven't been able to do all the kind of sweet, romantic stuff that usually is the bulk of a relationship. So I hope we get to have a little bit of a honeymoon before being struck by tragedy," the actress told TVLine.

"It would be nice to kind of get out of the muck and mire," she continued.

Scorsone also hopes that even though catastrophe will strike in "Grey's Anatomy" season 13, their love will conquer the odds.

While she believes that Amelia and Owen's happiness will be "hard-won," she wants them to be the couple that will shock everyone they lasted longer than the naysayers thought they would.

Apart from Amelia and Owen now sharing the same surname in "Grey's Anatomy" season 13, there's also the Nathan (Martin Henderson) and Meredith (Ellen Pompeo) hook-up dilemma, which will incur serious drama from Maggie (Kelly McCreary).

Lastly, "Grey's Anatomy" season 13 will no longer have Callie (Sara Ramirez) around. Ramirez has announced her departure from "Grey's Anatomy" before the season 12 finale.

Speaking up about the exit, show creator Shonda Rhimes admitted in an official statement picked up by Entertainment Weekly that she "had a different plan" for Callie, but even though that did not transpire, she has no problem with Ramirez wanting to  leave the show.

"I feel really good about the fact that she said that she wanted to take this break... I love the woman and I want everything for her. It all worked out in that sense, but I don't like to see anybody go," Rhimes said.