It's advised that viewers avoid getting attached to the characters of the brand new horror comedy "Scream Queens" as the show will kill off whoever necessary until the star-studded ensemble is just down to four by the end of the season. This means that 21 characters will all be victims of an all-out carnage. 

Ryan Murphy, who created the series with Brad Falchuk and Ian Brennan, dropped the bomb in a chat with The Hollywood Reporter, saying, "It's similar to American Horror Story in that it's anthological but different in that at the end of the first season there will only be four characters out of 25 left." 

These lucky girls will return for "Scream Queens" season 2 in a new type of horror fest but playing the same characters, and judging by Murphy's revelation, they must really be good at escaping the guy with the scythe. Death will basically be everywhere and their sorority sisters will be dying a gruesome death. 

"And those four in season two will go on to a new horror genre — like a sorority is a horror genre to me, it's a place where there were horror movies in the '80s like Sorority Row — and they will go on. That's the format of the show," Murphy described. 

Simply put, "Scream Queens" is a "sort of like a twist on American Horror Story: every season is a new season, a new setting, a new establishment — the difference being you will know some of the characters who will live." 

Set in a campus victimized by a chain of murders, "Scream Queens" season 1 will air on Sept. 22. Emma Roberts stars as Chanel Oberlin, the popular and difficult sorority Kappa House head. Jamie Lee Curtis is on board as anti-sorority dean Cathy Munsch. Skyler Samuels plays the role of Grace Gardner, who is determined to restore KKT to the glorious team it once was. 

Other stars set to appear in "Scream Queens" is Lea Michele, Abigail Breslin and Ariana Grande, as well as Nasim Pedrad, Oliver Hudson, Keke Palmer and Nick Jonas. Niecy Nash and Billie Lourd will be there, too.