Throughout the run of How to Get Away with Murder, key character Annalise Keating, along with her Keating 5, have figured in many cases and cover ups of their own, but this time around, it may be Annalise who finds herself as the accused.

Based on an exclusive trailer released on Entertainment Weekly, Annalise opens the season by welcoming her students to a new school year where they will be starting a Criminal Law clinic where selected students get to be 'practicing' lawyers.

However, her spiel is disrupted by a poster of her marked with the words killer, attached to the wall. As it turns out, hundreds of similar posters have been littered all over the campus and the gang seems set to figure out who is responsible for the vandalism.

The trailer promises "a mystery so killer that not everyone will make it out alive."

The season promises to be an exciting one since it will be following a new format as they strive to balance out tacking the main case and interesting cases of the week, which the show seemed to lose focus in the bottom half of the second season with the heavy emphasis on Rose's case, Variety reported.

Executive Producer Pete Nowalk teased that the killer of Wes' father will be revealed this season and hinted that it will be uncovered either at the beginning or the end of the season.

"There are two options for me — it's either in the first minute in the show, or that's a longer mystery because it's a more complicated story," he said.

While many people think that Frank is out of the picture after it was revealed what his role was in Annalise's miscarriage, fans will be happy to note that Charlie Weber, the actor who plays the role, is still listed as an original cast member.

You know, it's not about Frank getting back on the team and going to court. He doesn't give a s–t about that. He just wants things to be OK with Annalise," Weber said in TVLine.

How to Get Away with Murder returns to ABC on September 22.