Scream Queens, a satirical black comedy TV series, will introduce a new killer and a new setting for their second season.

Dean Cathy Munsch (Jamie Lee Curtis), who was also the former dean of Wallace University, will own a hospital which is a former asylum. She took advantage of her fame "as an icon of a new movement called new-new feminism ... into purchasing a hospital."

 There will also be a three-year time jump where Chanel Oberlin (Emma Roberts), Libby Putney (Abigail Breslin), and Sadie Swenson (Billie Lourd) works in the hospital under Dean Munsch.

 According to TVLine, Ian Brennan, executive producer of Scream Queens, said "They've fallen from glamour, but they're trying to hold onto it as much as they can. It's funny seeing them try to hold onto their style when they have no money." Expect to see the Chanels desperately follow their fashion style despite their limited resources.

New addition in the group are John Stamos, who will be a surgeon named Brock Holt in the hospital and is "the recipient of the world's first complete hand transplant. [He] may have the hand of a brilliant surgeon, or [he] may have one from a squash player who killed his opponents", and Taylor Lautner, who will be Dr. Cassidy Cascada who has a mental illness and a suspect regarding incidents that happened in the institution.

Cecily Strong will also guest- star and will portray a patient in the hospital.

According in an article by Bustle, the killer will no longer be the Red Devil.

The new killer might be jived with the new hospital setting which presents a lot of horror opportunities than the campus set-up.

Brennan told Entertainment Weekly  " I think it's bloodier and funnier. I feel like we're leaning into the creepiness a little bit more, and a little bit more into the comedy as well."

Scream Queens will air on September 20 at 9 p.m. on FOX.